To get rid of fever blisters fast, use an oral antiviral medicine to promote healing and reduce the pain of the blister, according to WebMD. Topical creams and ointments may also be recommended.
There is no cure for fever blisters, which are sometimes referred to as "cold sores" or the virus, known as herpes simplex, or HSV, that causes them, according to WebMD. Most fever blisters simply go away without treatment, but using medicines to reduce the duration of the outbreak and prevent future outbreaks can make them more manageable.
Treatment methods vary based on whether treatment is for an initial outbreak or a chronic recurring outbreak. Oral antivirals are generally only recommended for initial outbreaks, and are available only by prescription. These medicines should be used when the initial symptoms of fever blisters occur, including itching and burning. Once a fever blister had developed, oral antiviral medications are of little use.
Topical ointments and creams are available in both prescription and nonprescription strengths, notes WebMD. These ointments are applied directly on the fever blister and can reduce the itching and pain associated with the condition. They can also shorten the time required for healing the fever blister completely.