According to dermatologist Dr. Amanda Oakley for DermNet New Zealand, angular cheilitis usually resolves itself. In some cases, it can be treated with the use of frequently applied lip balms or thick emollient ointments, topical antiseptics, topical or oral antibiotics and topical antifungal creams. Additional treatment options include oral antifungal medications, topical steroid ointments, nutritional supplements, filler injections or implants to build up the corners of the mouth.
There are some natural home remedies used to treat angular cheilitis, but they are not guaranteed to work. Honey might help to fight the infection if left on the affected area for 15 minutes, according to Home Remedy Shop. Aloe vera gel may relieve pain associated with angular cheilitis. Cocoa butter has strong moisturizing properties and can ease the symptoms of cracking and splitting if applied generously to the affected area two or three times daily. Rubbing cucumber on the area is thought to produce a cooling effect.
Home Remedy Shop recommends making a mixture of 2 tablespoons of tea tree oil, 1 tablespoon of vitamin E oil and half a tablespoon of petroleum jelly to apply to the affected area multiple times daily. Drinking plenty of water keeps the body hydrated and may help to prevent the condition.