The presence of squamous cells in urine does not imply that there is a medical problem, according to WebMD. It may mean that the urine sample is not as pure as it needs to be, and the doctor administrating the test may ask for another sample.
Squamous cells are scaly, flat cells typically found in the top layers of the skin, notes WebMD. These cells are also located in the tissue that covers the inside of many organs, including the bladder, and in the tissue lining the passageways of the respiratory and digestive systems of the human body. As a result, squamous cells may make their way into urine samples purely by chance, without indicating the presence of a medical condition that requires intervention.
Other cells that may make their way into urine samples include red or white blood cells, bacteria, yeast cells, crystals and casts, as noted by WebMD. The presence of blood cells in urine may indicate inflammation or disease, while the presence of casts could indicate kidney disease. Certain kinds of crystals or large numbers of them may indicate the presence of kidney stones, although healthy people have a small number of crystals in their urine. The presence of bacteria or yeast implies some kind of infection.