The maximum dose of Ibuprofen for adults is 800 milligrams up to four times per day, totaling 3,200 milligrams per 24 hour period, according to Drugs.com. Exceeding the recommended dosage can cause damage to the stomach and intestines, as well as life threatening conditions, such as heart attack.
Some people should only take Ibuprofen under the guidance of a medical professional. This includes anyone with a history of heart attack or stroke, congestive heart failure, asthma, liver or kidney disease, stomach ulcers, or smoking. Stomach bleeding or perforation of the intestines can occur without warning when taking Ibuprofen, according to Drugs.com.