The most common reactions to the shingles vaccine include a headache and skin reactions such as redness, swelling or soreness at the shot site, according to the Centers for Disease Control and Prevention. No serious reactions have been associated with the shingles vaccine, as of March 2015.
In some cases, people may develop a rash that resembles chickenpox at the injection site, according to the CDC. Until healed, this rash should remain covered. People who are allergic to gelatin or the antibiotic neomycin may develop a life-threatening reaction to the shingles vaccine, according to MedlinePlus. Symptoms of an allergic reaction include wheezing, swelling of the throat and a rapid heartbeat. If this occurs, a health care provider should be contacted immediately.