An elevated prostate-specific antigen, or PSA, level indicates a greater risk of prostate cancer, according to the National Cancer Institute. Men with PSA levels above 4.0 nanograms per milliliter are at added risk of cancer and may need a biopsy to rule out prostate cancer.
While elevated PSA levels do not always indicate prostate cancer, the higher the level, the more likely it is that cancer is present, notes the National Cancer Institute. In addition, a continued PSA elevation from year to year may also indicate cancer. Monitoring PSA levels after initial treatment for prostate cancer can also help to determine if prostate cancer has recurred.