Possible side effects of a Xiaflex injection include pain, swelling, itching and redness at the injection site, states WebMD. Some patients may also experience swelling and pain in the elbow or underarm area, resulting from swollen lymph nodes after receiving an injection in the hand.
Individuals receiving a Xiaflex injection may experience serious side effects such as fever, chills and increasing swelling or redness at the injection site, according to WebMD. Other serious side effects include signs of nerve damage, such as tingling and numbness. A few patients may experience injury to the tendon of the hand.
Individuals experiencing serious side effects or signs of allergic reaction, such as rash, difficulty breathing, swelling of the tongue, face or throat, or severe dizziness should seek medical attention.