Side effects of using the Nicoderm transdermal patch include skin irritation at the application site, including redness, burning, stinging and mild itching. Other possible side effects of the Nicoderm patch are nausea, headache and dizziness, according to WebMD.
Rare side effects of the Nicoderm patch that require immediate medical attention include severe allergic reactions such as swelling of the lips or tongue, breathing difficulties, seizures and uneven heartbeat, reports Everyday Health. Individuals using the Nicoderm patch may also experience side effects that are attributed to symptoms of nicotine withdrawal rather than the patch itself. Symptoms of nicotine withdrawal include trouble sleeping, dizziness, anxiety and depression, says WebMD.