What Are Some Possible Side Effects of Allopurinol?


Quick Answer

Side effects of allopurinol include rash, stiffness or swelling in the joints, and pain in the ankle, knee or big toe joint. Other less common symptoms include abdominal pain, anxiety, constipation, depression and dizziness, according to Drugs.com. A person should alert their doctor immediately if they experience serious side effects such as pain or bleeding when urinating; decreased urination; fever; nausea; severe pain; numbness; or muscle weakness, states Everyday Health.

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Full Answer

Doctors prescribe allopurinal to treat gout, kidney stones, seizures, infections and high amounts of uric acid in the body, explains Everyday Health. It is also used to reduce ulcer relapses, prevent kidney transplant rejections and enhance survival following bypass surgery. Allopurinal works by lowering the production of uric acid in the body.

Patients with liver disease, kidney disease, high blood pressure or congestive heart failure should inform their doctors before taking allopurinol. Pregnant women, lactating mothers and patients on chemotherapy drugs must also inform their doctors, states Everyday Health. As allpurinol can reduce the blood cells in the body that are responsible for clotting blood and fighting infections, patients using the medication should keep away from people who are sick. Doctors typically order regular blood tests to monitor a patient's reaction to the drug.

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