A person should stop taking methotrexate only when it starts causing serious side effects. Methotrexate is a drug that is only used to treat serious conditions, such as cancer, and those people who do not respond to other medications, as noted by MedlinePlus. Before taking this medication, visit a doctor to assess the risks of using methotrexate.
People with excess fluid in the stomach area or around the lungs should let the doctor know before using this medication. There are certain medications that interact with methotrexate, such as naproxen, aspirin, salsalate, ibuprofen and all other anti-inflammatory nonsteroidal drugs. These medications and other health conditions tend to worsen the side effects of using methotrexate. In some situations, a doctor may require to first give a patient a low dosage while monitoring the patient to see the response.
Methotrexate can lead to a reduction in the number of blood cells made by the bone marrow. Symptoms associated with such a reduction include tiredness, chills, breath shortness, pale skin, sore throat among others. One should visit a doctor if he or she notices these symptoms. This medication can also lead to liver damage if taken for a long time, as stated by MedlinePlus. One can stop medication after consulting a doctor.