The possible negative side effects of piroxicam include skin itching, upset stomach, headache, blurred vision and dizziness, says RxList. The patient may also experience a stiff neck, easy bruising or bleeding, swelling of the feet, ankles and hands, mood and mental changes, and sudden weight gain, according to WebMD. Piroxicam also causes increased blood pressure and, in rare cases, liver damage.
Piroxicam is a nonsteroidal anti-inflammatory drug used to reduce joint stiffness, pain and swelling caused by arthritis. It works by reducing the production of inflammation-causing hormones in the body, explains WebMD. Piroxicam can also be used to treat gout attacks.
A patient should inform his doctor before taking piroxicam if he is allergic to it or to any other nonsteroidal anti-inflammatory drugs, since piroxicam might contain inactive ingredients that can trigger allergic reactions, notes WebMD. The patient should also not drive or use heavy machinery while taking piroxicam, since it can cause dizziness and drowsiness. The patient should inform his doctor if he experiences any signs of an allergic reaction such as difficulty breathing, hives and swelling of the face, tongue, lips or throat, advises RxList.
Piroxicam may interact with products such as aliskiren, lisinopril, corticosteroids, diuretics and lithium. It may also increase the chances of bleeding when taken with drugs such as anti-platelet drugs and blood thinners. A patient should not take piroxicam with drugs containing fever reducers or pain relievers such as aspirin or ibuprofen unless under the direct orders of a doctor, since they may increase the chances of side effects, explains WebMD.