Although it is possible to lose 10 pounds in two weeks, it is not healthy. It requires a drastic reduction of carbohydrates in the diet. For every gram of carbohydrate consumed, the body holds 3 grams of water; therefore, reducing carbohydrates reduces the amount of water stored in the body.
The Mayo Clinic recommends starting small, counting calories and eating from plates, not from packages. There are a few factors that determine weight loss, including: calories consumed, calories burned and water retention. On average, a moderately-active female over 14 years old normally burns between 2000 and 2200 calories per day; a male burns 2400-2800 calories per day.
In order to lose 10 pounds, a person must have a deficit of 35,000 calories, since it takes a deficit of 3500 calories to lose 1 pound of fat. In order for one to lose 10 pounds in two weeks, they must have a daily deficit of 2500 calories. If a woman eats 1000 calories per day during that two week period and exercises to burn around 1500 calories per day, she would lose 10 pounds of real weight; a man eating 1500 calories per day and burning around 1000 calories per day would also lose 10 pounds of real fat. However, this amount of stress placed on the body is very unhealthy and not recommended.