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What are possible causes of high protein in urine?

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Quick Answer

Possible causes of high protein in urine, or proteinuria, include kidney damage and overproduction of protein in the body. Other possible causes include trauma, infections, toxins, immune system disorders and medications. A condition called orthostatic proteinuria in certain people allows extra protein to get into the urine when standing, according to WebMD. Exposure to cold or heat, fever, emotional stress and vigorous training can also lead to a temporary increase in the level of protein in urine, notes Mayo Clinic.

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Diabetes and high blood pressure can cause kidney damage, making them the greatest risk factors for proteinuria. Native Americans, African Americans, Pacific Islanders and Hispanics are at a higher risk of developing high blood pressure and kidney disease, leading to proteinuria. Kidney disease damages kidney filters, causing proteins such as albumin to seep from the blood into the urine, states WebMD. Other risk factors include conditions such as multiple myeloma and amyloidosis, a family history of kidney disease, obesity, preeclampsia and being over 65 years of age.

The treatment of high protein in urine is dependent on its underlying cause, notes WebMD. Drugs such as ACE inhibitors and ARBs are occasionally prescribed for people with high blood pressure or diabetes. Treatment is not necessary for mild or temporary proteinuria.

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