An enlarged spleen can cause a feeling of pain or fullness in the left upper abdomen, according to Mayo Clinic. The pain sometimes spreads to the left shoulder. Other symptoms of an enlarged spleen include anemia, fatigue, frequent infections and easy bleeding.
Causes of an enlarged spleen include infections, liver diseases, hypersplenism and blood cancers, such as leukemia and Hodgkin's disease, explains the BaylorScott & White Health Education Library. Treatments available to those suffering from an enlarged spleen include medications aimed at eliminating the infection or disease, radiation therapy, blood transfusions and vaccinations. If treatments prove unsuccessful, the condition can require the surgical removal of the spleen.