Unfortunately, there are not any effective over-the-counter remedies for impetigo other than washing with soap and water, according to WebMD. Although over-the-counter antibacterial ointments are available, they are not strong enough to kill the bacteria that causes an impetigo infection.
Severe cases of impetigo require prescription-strength antibiotics and topical mupirocin ointment, which is also a prescription medication, states WebMD. Anyone with impetigo must use a clean towel each time he bathes, and these towels must be laundered separately to prevent the infection from spreading to other family members. All sores associated with impetigo should be kept covered to prevent the infection from spreading to other areas of the body or other people.