Effective over-the-counter pain relief medications, include Tylenol, Motrin, Advil, Aleve and Naprosyn, according to WebMD. Tylenol is a brand name of acetaminophen, while Motrin, Advil, Aleve and Naprosyn are non-steroidal anti-inflammatory drugs.
Acetaminophen-containing medications, such as Tylenol, are effective in reducing pain, muscle aches, stiffness and fever, states WebMD. However, they do not reduce inflammation. These types of medications are best used to treat mild to moderate pain.
Non-steroidal anti-flammatory drugs include ibuprofen and naproxen. Brand name NSAIDs, such as Motrin and Advil, provide the same benefits as acetaminophen-containing medications. However, they also reduce inflammation in the body, as explained by WebMD.