The best over-the-counter medications for acid reflux are antacids, H2-blockers and proton pump inhibitors, according to Healthline. Antacids include products like Alka-Seltzer, Maalox and Mylanta. Some examples of H2-blockers are Zantac, Pepcid and Tagamet. Most proton pump inhibitors are prescription only, but a few are available OTC.
If over-the-counter products do not effectively relieve acid reflux or acid reflux has damaged the esophagus, a doctor can prescribe stronger medication, according to Healthline. Often, a prescription-strength proton pump inhibitor may be required. PPIs block acid production and can help heal esophageal damage. If a person uses an OTC medication for acid reflux more than twice per week, Healthline recommends contacting a doctor. Severe cases of acid reflux can result in surgery.