The most effective oral medications and treatments for foot pain vary depending on the cause of the pain, according to WebMD. The most common and effective over-the-counter oral medications for pain are acetaminophen and nonsteroidal anti-inflammatory drugs.
The most common types of NSAIDs are ibuprofen and naproxen, states WebMD. Popular brands of ibuprofen are Advil and Motrin. Aleve and Naprosyn are examples of naproxen brands. NSAIDs relieve foot pain by reducing the production of the hormone that causes pain. Ibuprofen works differently by reducing the effectiveness of the pain receptors in the brain. Examples of popular ibuprofen brands are Tylenol and Aspirin-Free Excedrin.