Doctors usually prescribe a 10- to 14-day course of oral antibiotics to treat C. diff, or Clostridium difficile, according to WebMD. Many physicians also recommend taking probiotics and drinking plenty of liquids to prevent dehydration.
Doctors normally prescribe the antibiotic Flagyl first but may use other antibiotics if this treatment is not effective, according to WebMD. Approximately 25 percent of patients need a second round of antibiotics to relieve symptoms.
When C. diff patients take anti-diarrhea medications, their symptoms can worsen, so patients should not take over-the-counter medications without consulting a physician, according to WebMD. Monoclonal antibodies and fecal transplants are two of the newest C. diff treatments that physicians are researching as of 2015.