Peyronie's disease can be treated through medication and surgery, states the Mayo Clinic. Although the condition can go away on its own, it often remains or get worse over time. Most treatment methods are designed to reduce pain and facilitate sexual intercourse.
As of 2015, collagenase Clostridium histolyticum is the only FDA-approved treatment for Peyronie's disease and is used for men with a penile curvature of at least 30 degrees and substantial plaque buildup, according to Mayo Clinic. The medication is injected into the penis in the doctor's office, and it works by breaking down collagen. Other medications such as pentoxifylline, interferon and verapamil have also been used for Peyronie's disease.
For severe deformity, the doctor may recommend certain surgical procedures to straighten the curved penis, explains the Mayo Clinic. Options include suturing one side of the penis, removing scar tissue to make a graft to straighten the penis, and placing an implant into the penis. Another treatment option, iontophoresis, uses an electrical current to deliver medications to the penis. However, more research is needed to rate its effectiveness. If patients do not have severe penile curvature, experience only mild pain or are still able to have pain-free sex, doctors may wait to recommend treatment until symptoms worsen.