Q:

Which NSAIDS have the least serious side effects?

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Quick Answer

Nonsteroidal anti-inflammatory drugs that selectively block the COX-2 receptor only tend to have fewer side effects than those that block both the COX-1 and COX-2 receptors, according to the National Center for Biotechnology Information. NSAIDs of this type include celecoxib and diclofenac.

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Full Answer

Most NSAIDs affect both the COX-1 and COX-2 receptors as part of their mechanism of action, writes the National Center for Biotechnology Information. Blocking the action of these receptors is key to the anti-inflammatory and pain relief actions of these drugs, but blocking both receptors may cause undesired side effects. NSAIDs that are selective for the COX-2 receptor only are less likely to cause adverse gastrointestinal or cardiac events than nonselective NSAIDs such as ibuprofen.

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