Normal pediatric liver enzyme test results are 0 to 60 international units per liter for aspartate transaminase and 0 to 50 international units per liter for alanine transaminase, says the Children’s Liver Association for Support Services. Other normal results are 0 to 50 international units per liter for gamma-glutamyl transferase and 75 to 375 international units per liter for alkaline phosphatase.
AST and ALT liver enzymes are the ones most commonly elevated because of damaged cells or inflammation, says Mayo Clinic. Damaged or inflamed cells leak more chemicals, including enzymes, than normal into the bloodstream, potentially causing elevated enzymes on blood tests. The elevated levels could be discovered in a routine blood test, and in most cases, the issue is mild and temporary.
However, many health conditions and diseases contribute to the elevation of liver enzymes, including obesity, celiac disease, liver cancer, hypothyroidism and over-the-counter pain medicine such as acetaminophen. Autoimmune hepatitis, mononucleosis, pancreatitis, muscular dystrophy, hemochromatosis and Wilson's disease are some other causes, according to Mayo Clinic.
Although some of these and other causes are rare in children, pediatricians review the children's symptoms and medications to determine the specific cause. The pediatricians order tests or procedures other than a liver enzyme test to help them determine the cause, Mayo Clinic explains.