The normal estradiol level for a premenopausal female is 30 to 400 picograms per milliliter of blood, and the normal estradiol level for a postmenopausal female is 0 to 30 picograms per milliliter, states MedlinePlus. The normal estradiol level for a male is 10 to 50 picograms per milliliter.
Gene issues, such as Turner and Klinefelter syndromes, early puberty in girls, low body fat and rapid weight loss can cause abnormal estradiol results, according to MedlinePlus. Estrogen, birth control pills, testosterone, certain antibiotics, medicines for mental disorders and corticosteroids can affect estradiol level test results. Normal levels may vary with each laboratory.