Nonsurgical treatments for Peyronie's disease include oral medication, topical medication, external energy, intralesional treatment and combination therapies, according to the U.S. National Library of Medicine. The medical community has not agreed on the ideal method for treatment, as of 2011.
An accumulation of scar tissue, known as placque, in the penis causes Peyronie's disease, explains WebMD. Peyronie's disease causes the penis to bend upward or to the side, resulting in pain and difficulty during intercourse.
Physicians should treat the acute pain phase of Peyronie's disease conservatively, states the U.S. National Library of Medicine, which does not recommend any single oral medication for treatment of the acute phase of Peyronie's disease. Due to lack of information on the etiology of Peyronie's disease and limited controlled research studies, the medical community has not established a standard modality for treatment.