Nerium skin care products have potential side effects that include skin rash. It is unknown whether the products cause allergic reactions or toxicity in the blood, according to CBS News. Oleander, a poisonous plant, is the main ingredient in the skin cream.
Nerium oleander is a widely cultivated species of evergreen shrub that is among the most poisonous of common garden plants. As of 2015 a drug derived from the plant has been tested for efficacy in treating cancer but has not received FDA approval. The agency cites the possibility of the plant causing serious adverse effects, as reported by CBS News.