TriMix-gel requires a prescription from a licensed physician, due to the ingredients of the drug, according to the product's website. TriMix-gel is applied topically as a surrogate for medications that treat erectile dysfunction, such as Cialis, Viagra and Levitra, or as a substitute for medication injected into the penis.
Cialis, Viagra and Levitra are a class of drug called PDE inhibitors and should not be taken by everyone, states Everyday Health. Men who have medical conditions such as heart failure, inadequately controlled high or low blood pressure, or inadequately controlled diabetes are poor candidates for PDE inhibitors. TriMix-gel use is successful in approximately 40 percent of men whose erectile dysfunction cannot be treated with PDE inhibitors, as explained on the company website.