Myelofibrosis leukemia a disorder of the bone marrow in which the body loses its ability to produce normal blood cells, resulting in the formation of scar tissue in the bone marrow, according to Mayo Clinic. The scarring causes serious conditions such as anemia, fatigue, and swollen liver and spleen.
Myelofibrosis occurs as a result of generic mutation in the stem cells, which are the cells that form the blood, explains Mayo Clinic. As the mutated stem cells grow in number to form blood, they transmit the mutation to new cells, which affects blood formation. This leads to the production of insufficient blood cells.
The development of myelofibrosis is typically a gradual process, which rarely shows any symptoms and signs during its initial stages, says Mayo Clinic. However, it causes signs and symptoms over time. Patients of myelofibrosis may experience tiredness, weakness, breath shortness, night sweats and fever. They may also develop pale skin, bone pain and swollen spleen. It is advisable to seek medical attention if the signs and symptoms persist.
The treatment of myelofibrosis include stem cell transplant, blood transfusion and splenectomy, which is the removal of swollen spleen through surgery, notes Mayo Clinic. Although stem cell transplant is the only effective remedy for myelofibrosis, it is not suitable for all myelofibrosis patients and involves serious side effects such as graft-versus-host disease and cataracts. Over time, stem cell transplant may also cause another form of cancer.