Muscle relaxants are not available over the counter, and a physician must prescribe them, states MedlinePlus and Healthline. The physician may combine them with non-prescription products such as acetaminophen to relieve muscle spasms or neck and back pain. Cyclobenzaprine, methocarbamol and chlorzoxazone are effective prescription muscle relaxants, notes Healthline.
Naproxen, ibuprofen and aspirin are non-steroidal anti-inflammatory drugs, or NSAIDs, available without a prescription, as of 2015. They lessen disc inflammation and ease arthritis symptoms, notes MedlinePlus. Patients should avoid taking these over-the-counter medications for extended periods of time. Serious side effects, such as ulcers, bleeding and damage to the kidneys or liver, may develop from long-term use or overdosing.