As of 2012, there are no products sold in the United States that reverse pupil dilation, according the New York Times. Some eye doctors used dapiprazole to reverse pupil dilation, but the product is no longer available.
Eye doctors use special eye drops called mydratics to widen the pupil so that they can examine the retina and optic nerve, explains the New York Times. The effects of the drug take up to six hours to wear off and produce uncomfortable side effects such as blurred vision and sensitivity to light.
Dapriprazole, released in 1991, was designed to constrict the pupils, notes Matossian Eye Associates . However, the drug is expensive, slow-acting, and causes stinging and red eyes in patients. It is no longer sold in the United States.