Typically, the medicines used to treat gonorrhea are the antibiotics ceftriaxone, azithromycin and doxycycline, reports Mayo Clinic. Ceftriaxone is an injection, while patients take the other two antibiotics orally.
Over the decades, gonorrhea has developed a resistance to nearly every treatment available, according to the Centers for Disease Control and Prevention. This is why the CDC recommends a treatment approach with more than one antibiotic. As of 2015, some research is in progress regarding the effect of the medicine Factive when combined with azithromycin, as preliminary studies suggest the combination is highly effective, notes Mayo Clinic. If a person is allergic to one of the standard antibiotics, doctors usually prescribe Factive.