Medications with the side effect of difficult urination include Norpace, Hycodan, cephalosporins and Benadryl, according to RxList, WebMD and Drugs.com. Norpace treats heart arrhythmias and tachycardias, according to RxList.
Hycodan is an opiate used by adults and children over 6 to treat coughs, states RxList. Cephalosporins are antibiotics that are derivatives of Cephalosporium, a type of mold, says Drugs.com. There are three types: Cephalosporin N,C and P. N and C are related to penicillin, while P is a steroid. They act much the same as penicillin in that they keep bacteria from building cell walls and dividing. There are several generations of cephalosporins. Rocephin, a third-generation cephalosporin, treats dangerous bacterial infections such as meningitis. In addition to difficult urination, other side effects of Rocephin include yellow skin, bruising, chalk-colored stool, and a skin reaction accompanied by fever, blisters and peeling skin.
Benadryl is an antihistamine, but it's also used to treat insomnia, motion sickness and less serious forms of Parkinson's disease, according to Drugs.com. As it causes drowsiness and dizziness, patients should not drive or operate dangerous machinery while taking Benadryl. Patients with glaucoma, peptic ulcer, high blood pressure, asthma or an enlarged prostate should alert their doctors before taking Benadryl.