The best rated medications for curing itchy skin depend on the cause of the itch, states Mayo Clinic. Once the cause is identified, the patient may be given medications such as corticosteroid creams. If the itchy area is small, the doctor may prescribe a calcineurin inhibitor such as Protopic or Elidel.
A doctor may recommend over-the-counter oral anti-allergy medications, such as Zyrtec and Claritin, that do not make the patient sleepy. Medications such as Benadryl induce drowsiness, which can help the patient sleep at night, according to Mayo Clinic. Antidepressants such as Prozac and Zoloft may be prescribed to reduce various types of skin itching.