Medications to manage the symptoms of premenstrual dysphoric disorder, or PMDD, include antidepressants, oral contraceptives and GnRH agonists, according to MedicineNet. Some others include natural treatments such as calcium and vitamins B6 and E.
Several selective serotonin reuptake inhibitors, or SSRIs, normally prescribed for treating depression, are effective for treating symptoms of PMMD by regulating serotonin levels in the brain, notes MedicineNet. Some of these include Zoloft, Paxil, Celexa and Prozac. Oral contraceptives that interfere with the production of ovarian hormones and ovulation are also effective. Estrogen-suppressing medications, or GnRH agonists, including Zoladex, Synarel and Lupron, cause the cessation of menstruation, stopping PMMD symptoms. Although research on the use of natural treatments, including dietary supplements and chasteberry extract, are limited, they show some success, as of 2015.