Antacids such as Alka-Seltzer and Pepto-Bismol and acid reducers such as Pepcid AC and Nexium 24HR are among the best medicines for acid reflux as of 2015, according to WebMD. If these medicines fail to alleviate symptoms, visiting the doctor for a gastroesophageal disease screening is necessary.
Antacids counteract stomach acid, easing sour stomach, stomach upset and acid indigestion. Some contain simethicone to get rid of excess gas, while others contain magnesium or aluminum. Side effects from over use include constipation, stomach cramping and diarrhea, notes WebMD.
Acid reducers come in the form of histamine antagonists or proton pump inhibitors. Both of these types of medicines cut acid production in the stomach. An example of a combination acid reducer and antacid is Pepcid Complete, which both neutralizes and reduces the production of acids, reports WebMD.