The maximum daily dose for coenzyme Q10 supplements varies widely, with studies using from 50 milligrams to 1,200 milligrams for adults throughout the day, according to WebMD. Medical professionals have not established an ideal dosage level. However, manufacturers generally recommend a range of about 22-400 milligrams, according to Mayo Clinic.
CoQ10 daily dosages vary based on the reason for the therapy, notes Mayo Clinic. For example, 60 to 150 milligrams of CoQ10 were taken orally once a day for two to 12 weeks as an antioxidant. Two hundred milligrams were taken orally once a day for 12 weeks to prevent heart disease, while 50 to 100 milligrams were taken orally once a day for about 90 days to lower cholesterol levels. Patients have taken CoQ10 daily in 400-milligram doses orally for 12 weeks to reduce diabetes nerve pain.