Marfan syndrome is inherited in an autosomal dominant pattern. It involves the mutation of the FBN1 or fibrillin-1 gene, a so-called dominant gene, and so only one copy of the mutated gene will produce the syndrome in offspring.Continue Reading
Marfan syndrome affects the connective tissue of the body, rendering them weaker and more flexible than typical. It can result in a number of health problems including impaired vision as the lenses become dislocated or weak heart valves, causing irregular heartbeat, shortness of breath and more.
An individual carrying this dominant gene has a 50 percent chance of passing it along to their offspring. It is estimated that approximately 25 percent of Marfan syndrome cases are caused by a new, spontaneous mutation and not by inheritance of the faulty gene.Learn more about Conditions & Diseases