The number of pounds lost needed to equal one pant size reduction varies per individual. Most experts estimate that a loss of anywhere between five and ten pounds will equal reduction by one pant size. For six pant sizes, that equals about thirty to sixty pounds.
Everyone will lose weight differently and at a different rate. For overall health, it is more important to focus on inch loss rather than pound loss, but that inch loss will be evident through clothing fit. One to two pounds of weight loss per week is consistently stated as the healthiest rate of loss.