According to Runner's World magazine, running burns an average of approximately 100 calories per mile. Contrary to popular belief, running and walking a mile do not burn the same amount of calories; instead, running burns approximately 50 percent more calories per mile than walking.
Runner's World explains that when continuous exercise is performed, a person burns about five calories for every liter of oxygen consumed. Given this formula, the amount of calories any specific person would burn depends on the weight of the person and how much effort it takes for that person to run a mile. If a person in good physical shape is well-conditioned and takes in less oxygen during his mile run, he will burn fewer calories than a person who is not as physically fit.