How Many Calories Are in Meatloaf? estimates that there are 340 calories in a 9.88-ounce serving of meatloaf. It notes that meatloaf is high in saturated fat; 180 of the calories in one serving of meatloaf come from fat.

Meatloaf can be made into a low-calorie dish by substituting some of the traditional ingredients with healthier alternatives. Cooking Light suggests using a mixture of 92 percent lean ground beef and 96 percent extra lean ground beef with a smaller amount of ground pork to add moisture, or combining ground turkey breast with ground turkey or ground pork and adding extra liquid to the mix. The lower fat content in the meat can result in a drier meatloaf, so Cooking Light recommends adding higher amounts of liquid flavorings, such as ketchup or salsa.