There is no need for patients with vaginal candidiasis to take a second 150-milligram pill of Diflucan, according to Drugs.com. The medication is most always prescribed by doctors as a single, 150-milligram dose.
The recommended dose for other infections is dependant on the severity of the infection and individual response to therapy, explains Drugs.com. Patients with oropharyngeal candidiasis or esophageal candidiasis typically take 200 milligrams of Diflucan the first day and 100 milligrams daily for at least two weeks. Those suffering from acute cryptococcal meningitis often administer 400 milligrams of Diflucan on the first day and 200 milligrams thereafter for 10 to 12 weeks after the cerebral spinal fluid culture returns negative results.