Some possible long-term side effects of Adderall include depression, hostility and paranoia, according to DrugAbuse.com. Long-term use of Adderall can suppress the appetite and lead to malnutrition and weight loss. In children, this can impede natural growth. It can also cause cardiovascular problems, such as high blood pressure and heart arrhythmia, headaches, insomnia, difficulty concentrating and dry mouth.
Other potential side effects include fever, nausea, diarrhea and stomach aches, states WebMD. Alcohol in combination with Adderall can amplify some of the negative side effects of both substances, including the risk of dehydration and depression. Allergic reactions are uncommon but possible, and individuals should seek emergency medical attention if they display rashes or experience swelling, itching, lightheadedness or difficulty breathing while taking Adderall. Other possible side effects that require immediate attention are numbness, change in skin tone, uncontrollable body movements, seizures and fainting.
Long-term users can develop a tolerance for the drug and require larger, more frequent doses to achieve the same effect, explains DrugAbuse.com. Frequent users of the drug can develop a physical or psychological dependency on the drug and can experience withdrawal symptoms of depression, fatigue and sleeping disorders during cessation. Though there is no medicinal treatment available to ease withdrawal symptoms, as of 2015, individuals can seek other means to combat Adderall addiction, such as therapy and support groups.