Some long-term effects of using Excedrin are gastrointestinal issues, nausea, headaches and feeling jittery, according to Everyday Health. Excedrin use can also lead to overdose if taken in large quantities, causing side effects such as burning in the throat, confusion and dizziness.
Some of the other common side effects of Excedrin are heartburn and insomnia, as noted by Everyday Health. Serious side effects include difficulty breathing, wheezing, rash or hives, bloody or black tools, or swelling of the lips, face, eyes, throat or tongue. Other serious side effects include unusual bleeding, ringing in the ears, vomiting and persistent stomach pain. Speak to a doctor immediately if any of these symptoms occur.
Hypersensitivity is another possible long-term effect of taking Excedrin, according to Drugs.com. Hypersensitivity side effects include conjunctivitis, rhinitis, bronchospasm and anaphylaxis. People with asthma tend to have worsened hypersensitivity symptoms when taking such medications with aspirin.
Some side effects occur or worsen when Excedrin is taken in conjunction with other drugs, says Everyday Health. Speak to a doctor before taking this medication with other over-the-counter pain relievers, aspirin, blood thinners or seizure medications. Also practice caution when taking Excedrin with diabetes medications, steroids, blood pressure medications, diuretics or cold medications.