According to New Health Guide, the pain after a tooth extraction normally subsides after two to three days. The pain begins to subside after 12 hours and is normally manageable using over-the-counter or prescription medication. Pain from a wisdom tooth extraction often takes the longest to subside.
Pain that persists past 48 hours is an indicator of a dry socket. Mayo Clinic describes the dry socket as a condition where the blood clot that normally forms after an extraction dislodges, exposing bone and nerves. Dry sockets are very painful, and pain medication is largely ineffective at managing the pain. Instead, the dentist packs the socket with a dressing.