Depending on the age of the patient and any pre-existing conditions, such as liver disease or renal disease, Focalin XR (dexmethylphenidate hydrochloride) can last up to 12 hours after administration, according to its manufacturer, Novartis Pharmaceuticals Corporation. On average, after 12 hours, its plasma concentration decreases to sub-therapeutic levels.
Focalin XR is the extended-release equivalent of Focalin, which contains time-release beads that release the medication twice, notes Novartis. Therefore, the drug reaches its maximum concentration in the blood twice, the first time at around 1.5 hours after administration and the second at around 6.5 hours after administration. The drug leaves the system entirely in about 24 hours after administration.