How Long Does It Take the Depo-Provera Shot to Wear Off?

Generally, it takes 3 to 6 months for Depo-Provera shots to wear off after the injections stop, according to NetDoctor. The exact time it takes to reach full fertility depends on how long the treatments lasted. Additionally, as all women are different, there is no specific answer to this question.

After 10 to 12 weeks, the effectiveness of the Depo-Provera, which is also known as a progesterone injection, decreases. Another injection is needed to ensure the woman does not become pregnant. Because all women are different, the duration of time it takes for a woman to reach full fertility after regular injections stop varies.