BuSpar stays in the body for at least two weeks, according to MedicineNet. It is important that MAO inhibitors not be taken within two weeks of stopping BuSpar, as most of them react badly with it.
As with all medicines, it is unwise to change anything with regard to using BuSpar without a doctor's supervision, cautions MedicineNet. It is also crucial to inform the doctor of all other medicines being taken before beginning BuSpar. This includes both prescription and over-the-counter drugs, including herbal remedies, as discussed at MedicineNet.com. Specific types of medicines that may react unfavorably with BuSpar, include medications that attempt to either rid the body of BuSpar more quickly, or slow down its exit, both by acting on certain liver enzymes.