What is a list of Y-linked genetic disorders?


Quick Answer

Y-linked genetic disorders include 46,XX testicular disorder of sex development, 47,XYY development, 48,XXYY syndrome and Y chromosome infertility, as reported by the United States National Library of Medicine. The Y chromosome is one of the two sex chromosomes that are present in humans, and the Y chromosome is present in males. Males will have both an X and a Y chromosome while females will possess two X chromosomes.

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Full Answer

The 46,XX testicular disorder of sex development happens when one of the X chromosomes carry a sex-determining region Y, or SRY, gene. As a result, the fetus will develop as a male despite the fact that it does not have a Y chromosome.

The 47,XYY syndrome happens when males have one X chromosome and two Y chromosomes. This syndrome is normally associated with males who have a tall stature and learning problems.

The 48,XXYY syndrome happens when males have two X chromosomes and two Y chromosomes. In these situations, the extra genetic material prevents the males from developing functional testes. Testosterone levels will also be reduced.

Y chromosome infertility happens when genetic material from the Y chromosome is deleted. This causes the affected individual to become infertile, as the gene deletion will most likely affect the individual's ability to produce the necessary proteins needed for sperm production.

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