Treatment for lesions caused by the human immunodeficiency virus, or HIV, varies based on the lesion type, location and size, according to the University of California, San Francisco. Examples of HIV-related lesions include fungal, viral, bacterial and neoplastic lesions.
Fungal lesions are treated systemically or topically, and treatment continues for seven days, notes the University of California, San Francisco. Topical medications, such as clotrimazole, are kept in the mouth for up to 30 minutes. Systemic medications, including fluconazole and ketoconazole, are typically taken in pill form. Viral lesions, including herpes zoster and herpes simplex, are treated with oral medications such as acyclovir. Human papillomavirus lesions are removed surgically. Bacterial lesions often develop as a result of the sudden onset of periodontal disease. Treatment includes plaque removal, scaling, local debridement, root planing and irrigation with povidone-iodine. Ongoing treatment includes the use of a medicated mouthwash and prescription medications.
Treatment for neoplastic lesions depends on location, number and size of the lesions, explains the University of California, San Francisco. Large lesions that interfere with talking and eating are treated with localized intralesional chemotherapy or through surgery. Well-circumcised, small lesions are treated with intralesional vinblastine or surgery. Neoplastic lesions, including those caused by Kaposi's sarcoma, are blue, purple or red in color. The hard palate is the most common oral location for the lesions, and they can appear flat or raised. Neoplastic lesions develop as a single lesion or in multiples.