L-glutathione skin whitening involves increasing the production of glutathione in the liver to neutralize and eliminate free radicals and detoxify cells. It inhibits the activity of an enzyme known as tyrosinase, leading to a skin whitening effect when taken orally or intravenously, according to PubMed Central. Topical application of L-glutathione is not recommended, as it is highly unstable when in liquid form and decomposes easily.Continue Reading
L-glutathione is the reduced form of glutathione and is also known as tripeptide glutathione or GSH, says PubMed Central. It changes melanin values and the skin's moisture content, leading to younger, fairer skin. Glutathione in its oxidized form is also known as GSSG and is used in topical skin whitening lotions, as it converts to L-glutathione when absorbed by the skin.
In addition to skin whitening, L-glutathione improves skin firmness, reduces wrinkles and smooths fine lines. To use L-glutathione topically, apply it twice daily on clean skin, as indicated by PubMed Central. Taking glutathione intravenously has better results, as oral supplementation of glutathione is not readily absorbed by the body, says WebMD. Long-term use of glutathione may result in low zinc levels or asthmatic attacks in those who are prone to asthma or wheezing and may interact adversely with other supplements or medication.Learn more about Medications & Vitamins