The active ingredients in each Excedrin Migraine tablet are 250 milligrams of acetaminophen, 250 milligrams of aspirin and 65 milligrams of caffeine, according to the official company website. Acetaminophen and aspirin are pain relievers, while caffeine helps the pain relievers work more effectively.
The inactive ingredients in the medication are benzoic acid, carnuba wax, hydroxypropyl cellulose, hydroxypropyl methylcellulose, microcrystalline cellulose, mineral oil, polysorbate 20, povidone, propylene glycol, simethicone emulsion, sorbitan monolaurate and stearic acid, states the company website. Excedrin Migraine may also contain FD&C blue no. 1 and titanium dioxide.
Common side effects of Excedrin Migraine include nausea, vomiting, stomach upset, restlessness and insomnia, according to WebMD. Serious side effects include severe dizziness or fainting, persistent stomach pain, ringing in ears, irregular heartbeat, and easy bruising or bleeding. Black or tarry stools and vomit that looks like coffee grounds are also among the serious side effects for Excedrin Migraine.
People who have ever had an allergic reaction to aspirin or other nonsteroidal anti-inflammatory medications, or who have aspirin-sensitive asthma, should not take Excedrin Migraine, notes WebMD. People with blood clotting disorders, anemia, ulcers, gout and poorly controlled diabetes should use Excedrin Migraine with caution. People with kidney and liver disease, high blood pressure, and heart disease should also use Excedrin Migraine with caution.